Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

Diana G. Adlowitz; Jennifer Barnard; Jamie N. Biear; Christopher Cistrone; Teresa Owen; Wensheng Wang; Arumugam Palanichamy; Ezinma Ezealah; Debbie Campbell; Chungwen Wei; R. John Looney; Inaki Sanz; Jennifer H. Anolik

doi:10.1371/journal.pone.0128269

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Open Access

Peer-reviewed

Research Article

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

Diana G. Adlowitz,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Jennifer Barnard,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Jamie N. Biear,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Christopher Cistrone,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Teresa Owen,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Wensheng Wang,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Arumugam Palanichamy,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Ezinma Ezealah,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Debbie Campbell,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Chungwen Wei,

Affiliation Department of Medicine, Emory University, Atlanta, Georgia, 30332, United States of America
⨯
R. John Looney,

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯
Inaki Sanz,

Affiliation Department of Medicine, Emory University, Atlanta, Georgia, 30332, United States of America
⨯
Jennifer H. Anolik

* E-mail: Jennifer_anolik@urmc.rochester.edu

Affiliation Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, 14642, United States of America
⨯

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

Diana G. Adlowitz,
Jennifer Barnard,
Jamie N. Biear,
Christopher Cistrone,
Teresa Owen,
Wensheng Wang,
Arumugam Palanichamy,
Ezinma Ezealah,
Debbie Campbell,
Chungwen Wei

Published: June 5, 2015
https://doi.org/10.1371/journal.pone.0128269

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B cells
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Memory B cells
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Cytokines
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Rheumatoid arthritis
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