Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer

Prasenjit Dey; Laura A. Velazquez-Villegas; Michelle Faria; Anthony Turner; Philp Jonsson; Paul Webb; Cecilia Williams; Jan-Åke Gustafsson; Anders M. Ström

doi:10.1371/journal.pone.0128239

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Peer-reviewed

Research Article

Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer

Prasenjit Dey,

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Laura A. Velazquez-Villegas,

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Michelle Faria,

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Anthony Turner,

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Philp Jonsson,

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Paul Webb,

Affiliation Genomic Medicine Program, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, United States of America
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Cecilia Williams,

Affiliations University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America, Science for Life Laboratory, Department of Proteomics and Nanotechnology, KTH—Royal Institute of Technology, 171 21 Stockholm, Sweden
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Jan-Åke Gustafsson,

Affiliations University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America, Department of BioSciences and Nutrition, Karolinska Institutet, Novum, S-141 57 Huddinge, Sweden
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Anders M. Ström

* E-mail: amstrom@uh.edu

Affiliation University of Houston, Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, 3605 Cullen Boulevard, Science & Engineering Research Center, Bldg 545, Houston, Texas 77204–5056, United States of America
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Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer

Prasenjit Dey,
Laura A. Velazquez-Villegas,
Michelle Faria,
Anthony Turner,
Philp Jonsson,
Paul Webb,
Cecilia Williams,
Jan-Åke Gustafsson,
Anders M. Ström

Published: May 26, 2015
https://doi.org/10.1371/journal.pone.0128239

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Transfection
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Gene expression
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Hypoxia
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