An Aberrant Splice Acceptor Site Due to a Novel Intronic Nucleotide Substitution in MSX1 Gene Is the Cause of Congenital Tooth Agenesis in a Japanese Family

Tadashi Tatematsu; Masashi Kimura; Mitsuko Nakashima; Junichiro Machida; Seishi Yamaguchi; Akio Shibata; Hiroki Goto; Atsuo Nakayama; Yujiro Higashi; Hitoshi Miyachi; Kazuo Shimozato; Naomichi Matsumoto; Yoshihito Tokita

doi:10.1371/journal.pone.0128227

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Peer-reviewed

Research Article

An Aberrant Splice Acceptor Site Due to a Novel Intronic Nucleotide Substitution in MSX1 Gene Is the Cause of Congenital Tooth Agenesis in a Japanese Family

Tadashi Tatematsu,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Masashi Kimura,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Dentistry Oral and Maxillofacial Surgery, Ogaki Municipal Hospital, Ogaki, Gifu, Japan, Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Mitsuko Nakashima,

Affiliation Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
⨯
Junichiro Machida,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Oral and Maxillofacial Surgery, Toyota Memorial Hospital, Toyota, Aichi, Japan
⨯
Seishi Yamaguchi,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Dentistry and Oral Surgery, Aichi Children’s Health and Medical Center, Obu, Aichi, Japan
⨯
Akio Shibata,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Hiroki Goto,

Affiliations Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan, Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Atsuo Nakayama,

Affiliation Department of Embryology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Yujiro Higashi,

Affiliation Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯
Hitoshi Miyachi,

Affiliation Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan
⨯
Kazuo Shimozato,

Affiliation Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Aichi, Japan
⨯
Naomichi Matsumoto,

Affiliation Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
⨯
Yoshihito Tokita

* E-mail: tokita@inst-hsc.jp

Affiliation Department of Perinatology, Institute for Developmental Research, Aichi-Human Service Center, Kasugai, Aichi, Japan
⨯

An Aberrant Splice Acceptor Site Due to a Novel Intronic Nucleotide Substitution in MSX1 Gene Is the Cause of Congenital Tooth Agenesis in a Japanese Family

Tadashi Tatematsu,
Masashi Kimura,
Mitsuko Nakashima,
Junichiro Machida,
Seishi Yamaguchi,
Akio Shibata,
Hiroki Goto,
Atsuo Nakayama,
Yujiro Higashi,
Hitoshi Miyachi

Published: June 1, 2015
https://doi.org/10.1371/journal.pone.0128227

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