Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Hanneke Hoelen; Arnaud Zaldumbide; Wouter F. van Leeuwen; Ellen C. W. Torfs; Marten A. Engelse; Chopie Hassan; Robert Jan Lebbink; Eelco J. de Koning; Maaike E. Resssing; Arnoud H. de Ru; Peter A. van Veelen; Rob C. Hoeben; Bart O. Roep; Emmanuel J. H. J. Wiertz

doi:10.1371/journal.pone.0128206

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Open Access

Peer-reviewed

Research Article

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Hanneke Hoelen,

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Arnaud Zaldumbide,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Wouter F. van Leeuwen,

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Ellen C. W. Torfs,

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Marten A. Engelse,

Affiliation Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Chopie Hassan,

Affiliation Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
⨯
Robert Jan Lebbink,

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Eelco J. de Koning,

Affiliation Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Maaike E. Resssing,

Affiliations Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Arnoud H. de Ru,

Affiliation Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
⨯
Peter A. van Veelen,

Affiliation Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
⨯
Rob C. Hoeben,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Bart O. Roep,

Affiliation Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
⨯
Emmanuel J. H. J. Wiertz

* E-mail: e.wiertz@umcutrecht.nl

Affiliation Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Hanneke Hoelen,
Arnaud Zaldumbide,
Wouter F. van Leeuwen,
Ellen C. W. Torfs,
Marten A. Engelse,
Chopie Hassan,
Robert Jan Lebbink,
Eelco J. de Koning,
Maaike E. Resssing,
Arnoud H. de Ru

Published: June 24, 2015
https://doi.org/10.1371/journal.pone.0128206

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