Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase

Terence W. Prendiville; Haidong Guo; Zhiqiang Lin; Pingzhu Zhou; Sean M. Stevens; Aibin He; Nathan VanDusen; Jinghai Chen; Li Zhong; Da-Zhi Wang; Guangping Gao; William T. Pu

doi:10.1371/journal.pone.0128105

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Open Access

Peer-reviewed

Research Article

Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase

Terence W. Prendiville,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Haidong Guo,

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Zhiqiang Lin,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Pingzhu Zhou,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Sean M. Stevens,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Aibin He,

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
⨯
Nathan VanDusen,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Jinghai Chen,

Affiliation Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Li Zhong,

Affiliation Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Da-Zhi Wang,

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, 1350 Massachusetts Ave, Cambridge, Massachusetts, United States of America
⨯
Guangping Gao,

Affiliation Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
William T. Pu

* E-mail: wpu@pulab.org

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase

Terence W. Prendiville,
Haidong Guo,
Zhiqiang Lin,
Pingzhu Zhou,
Sean M. Stevens,
Aibin He,
Nathan VanDusen,
Jinghai Chen,
Li Zhong,
Da-Zhi Wang

Published: May 29, 2015
https://doi.org/10.1371/journal.pone.0128105

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Heart
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Gene identification and analysis
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