Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

Andreia V. Pinho; Mohammed Bensellam; Elke Wauters; Maxine Rees; Marc Giry-Laterriere; Amanda Mawson; Le Quan Ly; Andrew V. Biankin; Jianmin Wu; D. Ross Laybutt; Ilse Rooman

doi:10.1371/journal.pone.0128012

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Open Access

Peer-reviewed

Research Article

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

Andreia V. Pinho,

Affiliations Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia, St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia
⨯
Mohammed Bensellam,

Affiliations St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst NSW, Australia
⨯
Elke Wauters,

Affiliation Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
⨯
Maxine Rees,

Affiliation Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia
⨯
Marc Giry-Laterriere,

Affiliations Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia, St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia
⨯
Amanda Mawson,

Affiliation Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia
⨯
Le Quan Ly,

Affiliation Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia
⨯
Andrew V. Biankin,

Affiliations Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Jianmin Wu,

Affiliations Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia, St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia
⨯
D. Ross Laybutt,

Affiliations St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst NSW, Australia
⨯
Ilse Rooman

* E-mail: i.rooman@garvan.org.au

Affiliations Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst NSW, Australia, St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia, Randwick NSW, Australia, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
⨯

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

Andreia V. Pinho,
Mohammed Bensellam,
Elke Wauters,
Maxine Rees,
Marc Giry-Laterriere,
Amanda Mawson,
Le Quan Ly,
Andrew V. Biankin,
Jianmin Wu,
D. Ross Laybutt

Published: June 5, 2015
https://doi.org/10.1371/journal.pone.0128012

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Gene expression
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