Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

Jens O. Watzlawik; Robert J. Kahoud; Ryan J. O’Toole; Katherine A. M. White; Alyssa R. Ogden; Meghan M. Painter; Bharath Wootla; Louisa M. Papke; Aleksandar Denic; Jill M. Weimer; William A. Carey; Moses Rodriguez

doi:10.1371/journal.pone.0128007

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Peer-reviewed

Research Article

Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

Jens O. Watzlawik,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Robert J. Kahoud,

Affiliations Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Ryan J. O’Toole,

Affiliation Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America
⨯
Katherine A. M. White,

Affiliation Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America
⨯
Alyssa R. Ogden,

Affiliation Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America
⨯
Meghan M. Painter,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Bharath Wootla,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Louisa M. Papke,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Aleksandar Denic,

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Jill M. Weimer,

Affiliation Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America
⨯
William A. Carey,

Affiliation Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Moses Rodriguez

* E-mail: rodriguez.moses@mayo.edu

Affiliation Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯

Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

Jens O. Watzlawik,
Robert J. Kahoud,
Ryan J. O’Toole,
Katherine A. M. White,
Alyssa R. Ogden,
Meghan M. Painter,
Bharath Wootla,
Louisa M. Papke,
Aleksandar Denic,
Jill M. Weimer

Published: May 28, 2015
https://doi.org/10.1371/journal.pone.0128007

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