Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis

Yan Chen; Heng Yan; Zhiqiang Song; Fangru Chen; Huan Wang; Jun Niu; Xiaowei Shi; Dongmei Zhang; Na Zhang; Zhifang Zhai; Baiyu Zhong; Liangjin Cheng; Tian Qian; Fei Hao

doi:10.1371/journal.pone.0127957

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Open Access

Peer-reviewed

Research Article

Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis

Yan Chen,

Current address: Department of Dermatology, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Heng Yan,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Zhiqiang Song,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Fangru Chen,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Huan Wang,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Jun Niu,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Xiaowei Shi,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Dongmei Zhang,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Na Zhang,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Zhifang Zhai,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Baiyu Zhong,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Liangjin Cheng,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Tian Qian,

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯
Fei Hao

* E-mail: haofei62@medmail.com.cn

Affiliation Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China
⨯

Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis

Yan Chen,
Heng Yan,
Zhiqiang Song,
Fangru Chen,
Huan Wang,
Jun Niu,
Xiaowei Shi,
Dongmei Zhang,
Na Zhang,
Zhifang Zhai

Published: June 5, 2015
https://doi.org/10.1371/journal.pone.0127957

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Psoriasis
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Small interfering RNA
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Immunohistochemistry techniques
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Intradermal injections
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