Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Takanobu Nagata; Hideo Yasukawa; Sachiko Kyogoku; Toyoharu Oba; Jinya Takahashi; Shoichiro Nohara; Tomoko Minami; Kazutoshi Mawatari; Yusuke Sugi; Koutatsu Shimozono; Sylvain Pradervand; Masahiko Hoshijima; Hiroki Aoki; Yoshihiro Fukumoto; Tsutomu Imaizumi

doi:10.1371/journal.pone.0127942

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Open Access

Peer-reviewed

Research Article

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Takanobu Nagata,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Hideo Yasukawa ,

* E-mail: yahideo@med.kurume-u.ac.jp

Affiliations Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan, Cardiovascular Research Institute, Kurume University, Kurume, Fukuoka, Japan
⨯
Sachiko Kyogoku,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Toyoharu Oba,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Jinya Takahashi,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Shoichiro Nohara,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Tomoko Minami,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Kazutoshi Mawatari,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Yusuke Sugi,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Koutatsu Shimozono,

Affiliation Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
⨯
Sylvain Pradervand,

Affiliation Lausanne Genomic Technologies Facility (LGTF), University of Lausanne, Lausanne, Switzerland
⨯
Masahiko Hoshijima,

Affiliation Department of Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Hiroki Aoki,

Affiliation Cardiovascular Research Institute, Kurume University, Kurume, Fukuoka, Japan
⨯
Yoshihiro Fukumoto,

Affiliations Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan, Cardiovascular Research Institute, Kurume University, Kurume, Fukuoka, Japan
⨯
Tsutomu Imaizumi

Affiliation Fukuoka Sanno Hospital and International University of Health and Welfare, Fukuoka, Japan
⨯

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

Takanobu Nagata,
Hideo Yasukawa,
Sachiko Kyogoku,
Toyoharu Oba,
Jinya Takahashi,
Shoichiro Nohara,
Tomoko Minami,
Kazutoshi Mawatari,
Yusuke Sugi,
Koutatsu Shimozono

Published: May 26, 2015
https://doi.org/10.1371/journal.pone.0127942

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