MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4

Lynnette Marcar; Bianca Ihrig; John Hourihan; Susan E. Bray; Philip R. Quinlan; Lee B. Jordan; Alastair M. Thompson; Ted R. Hupp; David W. Meek

doi:10.1371/journal.pone.0127713

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Peer-reviewed

Research Article

MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4

Lynnette Marcar,

Current address: Department of Radiation Oncology, CNY 149–4406, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, United States of America

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
⨯
Bianca Ihrig,

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
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John Hourihan,

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
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Susan E. Bray,

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
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Philip R. Quinlan,

Affiliations School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, United Kingdom, School of Computer Science, University of Nottingham, Jubilee Campus, Nottingham, United Kingdom, Advanced Data Analysis Centre, University of Nottingham, Nottingham, United Kingdom
⨯
Lee B. Jordan,

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
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Alastair M. Thompson,

Affiliation M. D. Anderson Cancer Center, University of Texas, 1400 Pressler Drive, Unit 1484, Houston, United States of America
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Ted R. Hupp,

Affiliation p53 Signal Transduction Laboratory, Edinburgh Cancer Research UK Centre, The University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom
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David W. Meek

* E-mail: d.w.meek@dundee.ac.uk

Affiliation Division of Cancer Research, University of Dundee, Clinical Research Centre and Jacqui Wood Cancer Centre, Ninewells Hospital, James Arrott Drive, Dundee, United Kingdom
⨯

MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4

Lynnette Marcar,
Bianca Ihrig,
John Hourihan,
Susan E. Bray,
Philip R. Quinlan,
Lee B. Jordan,
Alastair M. Thompson,
Ted R. Hupp,
David W. Meek

Published: May 22, 2015
https://doi.org/10.1371/journal.pone.0127713

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