A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice

Open Access

Peer-reviewed

Research Article

A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APP_SweDI Mice

Baiba Jansone ,

* E-mail: baiba.jansone@lu.lv

Affiliation Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia
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Inga Kadish,

Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Thomas van Groen,

Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Ulrika Beitnere,

Affiliation Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia
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Doyle Ray Moore,

Affiliation Department of Pharmacology/Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Aiva Plotniece,

Affiliation Latvian Institute of Organic Synthesis, Riga, Latvia
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Karlis Pajuste,

Affiliation Latvian Institute of Organic Synthesis, Riga, Latvia
⨯
Vija Klusa

Affiliation Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia
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Mouse models
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Hippocampus
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Genetically modified animals
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Alzheimer's disease
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Learning and memory
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Blood-brain barrier
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Cingulate cortex
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Protein expression
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