Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients

Linlin Lu; Juan Zhou; Jian Shi; Xiao-juan Peng; Xiao-xiao Qi; Ying Wang; Fang-yuan Li; Fu-Yuan Zhou; Liang Liu; Zhong-Qiu Liu

doi:10.1371/journal.pone.0127524

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Open Access

Peer-reviewed

Research Article

Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients

Linlin Lu,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China
⨯
Juan Zhou,

Affiliation Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
⨯
Jian Shi,

Affiliations International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China, Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
⨯
Xiao-juan Peng,

Affiliation Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
⨯
Xiao-xiao Qi,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China
⨯
Ying Wang,

Affiliations International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China, Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
⨯
Fang-yuan Li,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China
⨯
Fu-Yuan Zhou,

Affiliation Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
⨯
Liang Liu,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau (SAR), 999078, PR China
⨯
Zhong-Qiu Liu

* E-mail: liuzq@gzucm.edu.cn

Affiliations International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China, Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China
⨯

Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients

Linlin Lu,
Juan Zhou,
Jian Shi,
Xiao-juan Peng,
Xiao-xiao Qi,
Ying Wang,
Fang-yuan Li,
Fu-Yuan Zhou,
Liang Liu,
Zhong-Qiu Liu

Published: May 26, 2015
https://doi.org/10.1371/journal.pone.0127524

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Protein metabolism
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