The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus

Open Access

Peer-reviewed

Research Article

Thomas R. J. Lovewell,

Affiliation School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
Andrew J. McDonagh,

Affiliation Dermatology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom
⨯
Andrew G. Messenger,

Affiliation Dermatology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom
⨯
Mimoun Azzouz,

Affiliation Department of Neuroscience, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
⨯
Rachid Tazi-Ahnini

* E-mail: r.taziahnini@sheffield.ac.uk

Affiliation School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
⨯

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DNA methylation
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Haplotypes
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Luciferase
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Single nucleotide polymorphisms
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Reporter gene assay
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Polymerase chain reaction
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Sequence alignment
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Transcription factors
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