Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

Bai-Wei Gu; Marisa Apicella; Jason Mills; Jian-Meng Fan; Dara A. Reeves; Deborah French; Gregory M. Podsakoff; Monica Bessler; Philip J. Mason

doi:10.1371/journal.pone.0127414

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Peer-reviewed

Research Article

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

Bai-Wei Gu,

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Marisa Apicella,

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Jason Mills,

Affiliation Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Jian-Meng Fan,

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Dara A. Reeves,

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Deborah French,

Affiliation Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Gregory M. Podsakoff,

Affiliation Division of Hematology, Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Monica Bessler,

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Philip J. Mason

* E-mail: masonp@email.chop.edu

Affiliation Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯

Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients

Bai-Wei Gu,
Marisa Apicella,
Jason Mills,
Jian-Meng Fan,
Dara A. Reeves,
Deborah French,
Gregory M. Podsakoff,
Monica Bessler,
Philip J. Mason

Published: May 18, 2015
https://doi.org/10.1371/journal.pone.0127414

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Induced pluripotent stem cells
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Telomeres
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Ribosomal RNA
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Telomere length
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