Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

Kimberly A. Coughlan; Thomas W. Balon; Rudy J. Valentine; Robert Petrocelli; Vera Schultz; Amanda Brandon; Gregory J. Cooney; Edward W. Kraegen; Neil B. Ruderman; Asish K. Saha

doi:10.1371/journal.pone.0127388

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Open Access

Peer-reviewed

Research Article

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

Kimberly A. Coughlan ,

Contributed equally to this work with: Kimberly A. Coughlan, Thomas W. Balon

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Thomas W. Balon ,

Contributed equally to this work with: Kimberly A. Coughlan, Thomas W. Balon

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Rudy J. Valentine,

Current address: Department of Kinesiology, Iowa State University, Ames, Iowa, United States of America

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Robert Petrocelli,

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Vera Schultz,

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Amanda Brandon,

Affiliation Diabetes and Obesity Program, Garvan Institute of Medical Research and School of Medical Sciences, University of NSW, Sydney, Australia
⨯
Gregory J. Cooney,

Affiliation Diabetes and Obesity Program, Garvan Institute of Medical Research and School of Medical Sciences, University of NSW, Sydney, Australia
⨯
Edward W. Kraegen,

Affiliation Diabetes and Obesity Program, Garvan Institute of Medical Research and School of Medical Sciences, University of NSW, Sydney, Australia
⨯
Neil B. Ruderman,

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯
Asish K. Saha

* E-mail: aksaha@bu.edu

Affiliation Department of Medicine, Section of Endocrinology and Diabetes, Boston University Medical Center, Boston, Massachusetts, United States of America
⨯

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

Kimberly A. Coughlan,
Thomas W. Balon,
Rudy J. Valentine,
Robert Petrocelli,
Vera Schultz,
Amanda Brandon,
Gregory J. Cooney,
Edward W. Kraegen,
Neil B. Ruderman,
Asish K. Saha

Published: May 21, 2015
https://doi.org/10.1371/journal.pone.0127388

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Glucose
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Skeletal muscles
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