C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

Johnathan Cooper-Knock; Joanna J. Bury; Paul R Heath; Matthew Wyles; Adrian Higginbottom; Catherine Gelsthorpe; J. Robin Highley; Guillaume Hautbergue; Magnus Rattray; Janine Kirby; Pamela J. Shaw

doi:10.1371/journal.pone.0127376

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Open Access

Peer-reviewed

Research Article

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

Johnathan Cooper-Knock,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Joanna J. Bury,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Paul R Heath,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Matthew Wyles,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Adrian Higginbottom,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Catherine Gelsthorpe,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
J. Robin Highley,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Guillaume Hautbergue,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Magnus Rattray,

Affiliation Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, United Kingdom
⨯
Janine Kirby,

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯
Pamela J. Shaw

* E-mail: pamela.shaw@sheffield.ac.uk

Affiliation Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, United Kingdom
⨯

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

Johnathan Cooper-Knock,
Joanna J. Bury,
Paul R Heath,
Matthew Wyles,
Adrian Higginbottom,
Catherine Gelsthorpe,
J. Robin Highley,
Guillaume Hautbergue,
Magnus Rattray,
Janine Kirby

Published: May 27, 2015
https://doi.org/10.1371/journal.pone.0127376

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