Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20

Hang Zhang; Changxin Huang; Yan Wang; Zhe Lu; Ningtong Zhuang; Dongjiu Zhao; Jianqin He; Liyun Shi

doi:10.1371/journal.pone.0127329

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Peer-reviewed

Research Article

Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20

Hang Zhang ,

Contributed equally to this work with: Hang Zhang, Changxin Huang

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯
Changxin Huang ,

Contributed equally to this work with: Hang Zhang, Changxin Huang

Affiliation Department of Oncology, Affiliated Hospital of School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯
Yan Wang,

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯
Zhe Lu,

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯
Ningtong Zhuang,

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯
Dongjiu Zhao,

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
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Jianqin He,

Affiliation Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
⨯
Liyun Shi

* E-mail: shi_liyun@msn.com

Affiliation Department of Basic Medical Science, Key Lab of Immunology and Molecular Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
⨯

Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20

Hang Zhang,
Changxin Huang,
Yan Wang,
Zhe Lu,
Ningtong Zhuang,
Dongjiu Zhao,
Jianqin He,
Liyun Shi

Published: May 20, 2015
https://doi.org/10.1371/journal.pone.0127329

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Apoptosis
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Hepatocytes
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Transfection
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DNA methylation
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Apoptotic signaling
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Immunoprecipitation
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Ubiquitination
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MicroRNAs
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