Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

Florry E. van den Boogaard; Jorrit J. Hofstra; Cornelis van ‘t Veer; Marcel M. Levi; Joris J. T. H. Roelofs; Tom van der Poll; Marcus J. Schultz

doi:10.1371/journal.pone.0127261

Loading metrics

Open Access

Peer-reviewed

Research Article

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

Florry E. van den Boogaard ,

* E-mail: f.e.vandenboogaard@amc.uva.nl

Affiliations Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Jorrit J. Hofstra,

Affiliation Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Cornelis van ‘t Veer,

Affiliations Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Marcel M. Levi,

Affiliation Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Joris J. T. H. Roelofs,

Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Tom van der Poll,

Affiliations Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Marcus J. Schultz

Affiliations Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

Feasibility and Safety of Local Treatment with Recombinant Human Tissue Factor Pathway Inhibitor in a Rat Model of Streptococcus pneumoniae Pneumonia

Florry E. van den Boogaard,
Jorrit J. Hofstra,
Cornelis van ‘t Veer,
Marcel M. Levi,
Joris J. T. H. Roelofs,
Tom van der Poll,
Marcus J. Schultz

Published: May 18, 2015
https://doi.org/10.1371/journal.pone.0127261

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pneumonia
Is the Subject Area "Pneumonia" applicable to this article?

Thanks for your feedback.
Anticoagulant therapy
Is the Subject Area "Anticoagulant therapy" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Pneumococcus
Is the Subject Area "Pneumococcus" applicable to this article?

Thanks for your feedback.
Hemorrhage
Is the Subject Area "Hemorrhage" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Cytokine therapy
Is the Subject Area "Cytokine therapy" applicable to this article?

Thanks for your feedback.
Coagulopathy
Is the Subject Area "Coagulopathy" applicable to this article?

Thanks for your feedback.