Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Derek C. Marshall; Susan K. Lyman; Scott McCauley; Maria Kovalenko; Rhyannon Spangler; Chian Liu; Michael Lee; Christopher O’Sullivan; Vivian Barry-Hamilton; Haben Ghermazien; Amanda Mikels-Vigdal; Carlos A. Garcia; Brett Jorgensen; Arleene C. Velayo; Ruth Wang; Joanne I. Adamkewicz; Victoria Smith

doi:10.1371/journal.pone.0127063

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Open Access

Peer-reviewed

Research Article

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Derek C. Marshall ,

Contributed equally to this work with: Derek C. Marshall, Susan K. Lyman

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Susan K. Lyman ,

Contributed equally to this work with: Derek C. Marshall, Susan K. Lyman

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Scott McCauley,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Maria Kovalenko,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Rhyannon Spangler,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Chian Liu,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Michael Lee,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Christopher O’Sullivan,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Vivian Barry-Hamilton,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Haben Ghermazien,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Amanda Mikels-Vigdal,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Carlos A. Garcia,

Affiliation Department of Process Development, Gilead Sciences, Inc., Oceanside, California, United States of America
⨯
Brett Jorgensen,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Arleene C. Velayo,

Affiliation Department of Process Development, Gilead Sciences, Inc., Oceanside, California, United States of America
⨯
Ruth Wang,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
Joanne I. Adamkewicz,

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
[ ... ],
Victoria Smith

* E-mail: victoria.smith@gilead.com

Affiliation Department of Biology, Gilead Sciences, Inc., Foster City, California, United States of America
⨯
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Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

Derek C. Marshall,
Susan K. Lyman,
Scott McCauley,
Maria Kovalenko,
Rhyannon Spangler,
Chian Liu,
Michael Lee,
Christopher O’Sullivan,
Vivian Barry-Hamilton,
Haben Ghermazien

Published: May 11, 2015
https://doi.org/10.1371/journal.pone.0127063

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