Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways

Jian Chang; Min Xue; Shilin Yang; Bing Yao; Bixiang Zhang; Xiaoping Chen; Ambra Pozzi; Ming-Zhi Zhang

doi:10.1371/journal.pone.0127030

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Peer-reviewed

Research Article

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways

Jian Chang ,

Contributed equally to this work with: Jian Chang, Min Xue

Affiliations Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
⨯
Min Xue ,

Contributed equally to this work with: Jian Chang, Min Xue

Affiliation Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America
⨯
Shilin Yang,

Affiliation Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America
⨯
Bing Yao,

Affiliation Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America
⨯
Bixiang Zhang,

Affiliation Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
⨯
Xiaoping Chen,

Affiliation Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
⨯
Ambra Pozzi,

Affiliation Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America
⨯
Ming-Zhi Zhang

* E-mail: ming-zhi.zhang@vanderbilt.edu

Affiliations Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical College, Xuzhou, China
⨯

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways

Jian Chang,
Min Xue,
Shilin Yang,
Bing Yao,
Bixiang Zhang,
Xiaoping Chen,
Ambra Pozzi,
Ming-Zhi Zhang

Published: May 26, 2015
https://doi.org/10.1371/journal.pone.0127030

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Lung and intrathoracic tumors
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Secondary lung tumors
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COX-2 inhibitors
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Cancer treatment
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Non-small cell lung cancer
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Signal inhibition
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Carcinogenesis
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Squamous cell lung carcinoma
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