Pathogenic Nontuberculous Mycobacteria Resist and Inactivate Cathelicidin: Implication of a Novel Role for Polar Mycobacterial Lipids

Jennifer R. Honda; Tamara Hess; Kenneth C. Malcolm; Alida R. Ovrutsky; Xiyuan Bai; Vida R. Irani; Karen M. Dobos; Edward D. Chan; Sonia C. Flores

doi:10.1371/journal.pone.0126994

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Peer-reviewed

Research Article

Pathogenic Nontuberculous Mycobacteria Resist and Inactivate Cathelicidin: Implication of a Novel Role for Polar Mycobacterial Lipids

Jennifer R. Honda ,

* E-mail: Jennifer.Honda@ucdenver.edu

Current address: Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

Affiliations Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, National Jewish Health, Denver, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
⨯
Tamara Hess,

Affiliation Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
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Kenneth C. Malcolm,

Affiliations Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, National Jewish Health, Denver, Colorado, United States of America
⨯
Alida R. Ovrutsky,

Affiliations National Jewish Health, Denver, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
⨯
Xiyuan Bai,

Affiliations National Jewish Health, Denver, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
⨯
Vida R. Irani,

Affiliation Department of Biology, Indiana University of Pennsylvania, Indiana, Pennsylvania, United States of America
⨯
Karen M. Dobos,

Affiliation Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Edward D. Chan,

Affiliations Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, National Jewish Health, Denver, Colorado, United States of America, Denver Veterans Affairs Medical Center, Denver, Colorado, United States of America
⨯
Sonia C. Flores

Affiliation Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Pathogenic Nontuberculous Mycobacteria Resist and Inactivate Cathelicidin: Implication of a Novel Role for Polar Mycobacterial Lipids

Jennifer R. Honda,
Tamara Hess,
Kenneth C. Malcolm,
Alida R. Ovrutsky,
Xiyuan Bai,
Vida R. Irani,
Karen M. Dobos,
Edward D. Chan,
Sonia C. Flores

Published: May 18, 2015
https://doi.org/10.1371/journal.pone.0126994

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Nontuberculous mycobacteria
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Lipids
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Cell walls
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