Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Hugo Brito; Ana Cláudia Martins; João Lavrado; Eduarda Mendes; Ana Paula Francisco; Sofia A. Santos; Stephan A. Ohnmacht; Nam-Soon Kim; Cecília M. P. Rodrigues; Rui Moreira; Stephen Neidle; Pedro M. Borralho; Alexandra Paulo

doi:10.1371/journal.pone.0126891

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Open Access

Peer-reviewed

Research Article

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Hugo Brito,

Affiliation Cell Function and Therapeutic Targeting Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Ana Cláudia Martins,

Affiliation Medicinal Chemistry Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
João Lavrado,

Affiliation Medicinal Chemistry Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Eduarda Mendes,

Affiliation Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Ana Paula Francisco,

Affiliation Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Sofia A. Santos,

Affiliations Medicinal Chemistry Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal, Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, United States of America
⨯
Stephan A. Ohnmacht,

Affiliation UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom
⨯
Nam-Soon Kim,

Affiliation Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Republic of Korea
⨯
Cecília M. P. Rodrigues,

Affiliation Cell Function and Therapeutic Targeting Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Rui Moreira,

Affiliation Medicinal Chemistry Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Stephen Neidle,

Affiliation UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom
⨯
Pedro M. Borralho ,

* E-mail: mapaulo@ff.ulisboa.pt (PMB); borralho@ff.ulisboa.pt (AP)

Affiliation Cell Function and Therapeutic Targeting Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯
Alexandra Paulo

* E-mail: mapaulo@ff.ulisboa.pt (PMB); borralho@ff.ulisboa.pt (AP)

Affiliation Medicinal Chemistry Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
⨯

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Hugo Brito,
Ana Cláudia Martins,
João Lavrado,
Eduarda Mendes,
Ana Paula Francisco,
Sofia A. Santos,
Stephan A. Ohnmacht,
Nam-Soon Kim,
Cecília M. P. Rodrigues,
Rui Moreira

Published: May 29, 2015
https://doi.org/10.1371/journal.pone.0126891

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Small interfering RNA
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