Anti-Inflammatory Action of an Antimicrobial Model Peptide That Suppresses the TRIF-Dependent Signaling Pathway via Inhibition of Toll-Like Receptor 4 Endocytosis in Lipopolysaccharide-Stimulated Macrophages

Do-Wan Shim; Kang-Hyuck Heo; Young-Kyu Kim; Eun-Jeong Sim; Tae-Bong Kang; Jae-Wan Choi; Dae-Won Sim; Sun-Hee Cheong; Seung-Hong Lee; Jeong-Kyu Bang; Hyung-Sik Won; Kwang-Ho Lee

doi:10.1371/journal.pone.0126871

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Open Access

Peer-reviewed

Research Article

Anti-Inflammatory Action of an Antimicrobial Model Peptide That Suppresses the TRIF-Dependent Signaling Pathway via Inhibition of Toll-Like Receptor 4 Endocytosis in Lipopolysaccharide-Stimulated Macrophages

Do-Wan Shim,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Kang-Hyuck Heo,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Young-Kyu Kim,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Eun-Jeong Sim,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Tae-Bong Kang,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Jae-Wan Choi,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Dae-Won Sim,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Sun-Hee Cheong,

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Seung-Hong Lee,

Affiliation Division of Food Bioscience, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Jeong-Kyu Bang,

Affiliation Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chungbuk, Republic of Korea
⨯
Hyung-Sik Won ,

* E-mail: wonhs@kku.ac.kr (HW); kwangho@kku.ac.kr (KL)

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯
Kwang-Ho Lee

* E-mail: wonhs@kku.ac.kr (HW); kwangho@kku.ac.kr (KL)

Affiliation Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Chungbuk, Republic of Korea
⨯

Anti-Inflammatory Action of an Antimicrobial Model Peptide That Suppresses the TRIF-Dependent Signaling Pathway via Inhibition of Toll-Like Receptor 4 Endocytosis in Lipopolysaccharide-Stimulated Macrophages

Do-Wan Shim,
Kang-Hyuck Heo,
Young-Kyu Kim,
Eun-Jeong Sim,
Tae-Bong Kang,
Jae-Wan Choi,
Dae-Won Sim,
Sun-Hee Cheong,
Seung-Hong Lee,
Jeong-Kyu Bang

Published: May 27, 2015
https://doi.org/10.1371/journal.pone.0126871

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