A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

Masahiro Fukasaka; Daisuke Asari; Eiji Kiyotoh; Arimichi Okazaki; Yasuyuki Gomi; Takeshi Tanimoto; Osamu Takeuchi; Shizuo Akira; Mitsuhiko Hori

doi:10.1371/journal.pone.0126849

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Peer-reviewed

Research Article

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

Masahiro Fukasaka ,

Contributed equally to this work with: Masahiro Fukasaka, Daisuke Asari

* E-mail: masahiro_fukasaka@gg.nitto.co.jp (MF); mitsuhiko_hori@gg.nitto.co.jp (MH)

Affiliation Life Science Research Center, Corporate Research & Development Division, Nitto Denko Corporation, Ibaraki, Osaka, Japan
⨯
Daisuke Asari ,

Contributed equally to this work with: Masahiro Fukasaka, Daisuke Asari

Affiliation Life Science Research Center, Corporate Research & Development Division, Nitto Denko Corporation, Ibaraki, Osaka, Japan
⨯
Eiji Kiyotoh,

Affiliation Life Science Research Center, Corporate Research & Development Division, Nitto Denko Corporation, Ibaraki, Osaka, Japan
⨯
Arimichi Okazaki,

Affiliation Life Science Research Center, Corporate Research & Development Division, Nitto Denko Corporation, Ibaraki, Osaka, Japan
⨯
Yasuyuki Gomi,

Affiliation Research and Production Technology Department, The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan
⨯
Takeshi Tanimoto,

Affiliation Research and Production Technology Department, The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan
⨯
Osamu Takeuchi,

Affiliation Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University, Shogoin Kawara-cho, Sakyo-ku, Kyoto, Japan
⨯
Shizuo Akira,

Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
⨯
Mitsuhiko Hori

* E-mail: masahiro_fukasaka@gg.nitto.co.jp (MF); mitsuhiko_hori@gg.nitto.co.jp (MH)

Affiliation Life Science Research Center, Corporate Research & Development Division, Nitto Denko Corporation, Ibaraki, Osaka, Japan
⨯

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

Masahiro Fukasaka,
Daisuke Asari,
Eiji Kiyotoh,
Arimichi Okazaki,
Yasuyuki Gomi,
Takeshi Tanimoto,
Osamu Takeuchi,
Shizuo Akira,
Mitsuhiko Hori

Published: May 15, 2015
https://doi.org/10.1371/journal.pone.0126849

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