4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8⁺ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

• Ho S. Oh,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Beom K. Choi,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Young H. Kim,

  Affiliation Immune Cell Production Unit, Program for Immunotherapeutic Research, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Don G. Lee,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Sunhee Hwang,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Myoung J. Lee,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Sang H. Park,

  Affiliation Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea

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• Yong-Soo Bae,

  Affiliation Department of Biological Sciences, Sungkyunkwan University, Suwon, Gyeonggi, Korea

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• Byoung S. Kwon

  * E-mail: bskwon@ncc.re.kr

  Current address: Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Korea

  Affiliations Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea, Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

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