Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

Kathleen E. Fischer; Jonathan A. L. Gelfond; Vanessa Y. Soto; Chul Han; Shinichi Someya; Arlan Richardson; Steven N. Austad

doi:10.1371/journal.pone.0126644

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Peer-reviewed

Research Article

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

Kathleen E. Fischer ,

* E-mail: fischerk@uab.edu

Current address: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Affiliations Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America, Department of Physiology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯
Jonathan A. L. Gelfond,

Affiliation Department of Epidemiology & Biostatistics, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯
Vanessa Y. Soto,

Affiliation Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯
Chul Han,

Affiliation Departments of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America
⨯
Shinichi Someya,

Affiliation Departments of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America
⨯
Arlan Richardson,

Current address: University of Oklahoma Health Science Center & Oklahoma City Veteran Administration Medical Center, Oklahoma City, Oklahoma, United States of America

Affiliations Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America, Department of Cellular & Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯
Steven N. Austad

Current address: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Affiliations Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America, Department of Cellular & Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

Kathleen E. Fischer,
Jonathan A. L. Gelfond,
Vanessa Y. Soto,
Chul Han,
Shinichi Someya,
Arlan Richardson,
Steven N. Austad

Published: May 15, 2015
https://doi.org/10.1371/journal.pone.0126644

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