Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway

Rongcai Yue; Xia Li; Bingyang Chen; Jing Zhao; Weiwei He; Hu Yuan; Xing Yuan; Na Gao; Guozhen Wu; Huizi Jin; Lei Shan; Weidong Zhang

doi:10.1371/journal.pone.0126603

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Open Access

Peer-reviewed

Research Article

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway

Rongcai Yue ,

Contributed equally to this work with: Rongcai Yue, Xia Li

Affiliations School of Pharmacy, Second Military Medical University, Shanghai, China, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
⨯
Xia Li ,

Contributed equally to this work with: Rongcai Yue, Xia Li

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Bingyang Chen,

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Jing Zhao,

Affiliation Department of Mathematics, Logistical Engineering University, Chongqing, China
⨯
Weiwei He,

Affiliation School of Pharmacy, East China University of Science and Technology, Shanghai, China
⨯
Hu Yuan,

Affiliation School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
⨯
Xing Yuan,

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Na Gao,

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Guozhen Wu,

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Huizi Jin,

Affiliation School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
⨯
Lei Shan ,

* E-mail: wdzhangy@hotmail.com (WZ); shanleish@yahoo.com.cn (LS)

Affiliation School of Pharmacy, Second Military Medical University, Shanghai, China
⨯
Weidong Zhang

* E-mail: wdzhangy@hotmail.com (WZ); shanleish@yahoo.com.cn (LS)

Affiliations School of Pharmacy, Second Military Medical University, Shanghai, China, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
⨯

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway

Rongcai Yue,
Xia Li,
Bingyang Chen,
Jing Zhao,
Weiwei He,
Hu Yuan,
Xing Yuan,
Na Gao,
Guozhen Wu,
Huizi Jin

Published: May 11, 2015
https://doi.org/10.1371/journal.pone.0126603

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