Lactobacillus fermentum ZYL0401 Attenuates Lipopolysaccharide-Induced Hepatic TNF-α Expression and Liver Injury via an IL-10- and PGE2-EP4-Dependent Mechanism

Pengfeng Jin; Yunbo Chen; Longxian Lv; Jianzhuan Yang; Haifeng Lu; Lanjuan Li

doi:10.1371/journal.pone.0126520

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Research Article

Lactobacillus fermentum ZYL0401 Attenuates Lipopolysaccharide-Induced Hepatic TNF-α Expression and Liver Injury via an IL-10- and PGE₂-EP4-Dependent Mechanism

Pengfeng Jin ,

Contributed equally to this work with: Pengfeng Jin, Yunbo Chen

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯
Yunbo Chen ,

Contributed equally to this work with: Pengfeng Jin, Yunbo Chen

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯
Longxian Lv,

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯
Jianzhuan Yang,

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯
Haifeng Lu,

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯
Lanjuan Li

* E-mail: ljli@zju.edu.cn

Affiliations State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University, Hangzhou, China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China
⨯

Lactobacillus fermentum ZYL0401 Attenuates Lipopolysaccharide-Induced Hepatic TNF-α Expression and Liver Injury via an IL-10- and PGE₂-EP4-Dependent Mechanism

Pengfeng Jin,
Yunbo Chen,
Longxian Lv,
Jianzhuan Yang,
Haifeng Lu,
Lanjuan Li

Published: May 15, 2015
https://doi.org/10.1371/journal.pone.0126520

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