Effects of the Pathogenic Mutation A117V and the Protective Mutation H111S on the Folding and Aggregation of PrP106-126: Insights from Replica Exchange Molecular Dynamics Simulations

• Lulu Ning,

  Affiliation State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, China

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• Dabo Pan,

  Affiliations State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, China, School of pharmaceutical technology, Qiandongnan National Polytechnic, Kaili, China

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• Yan Zhang,

  Affiliation School of Pharmacy, Lanzhou University, Lanzhou, China

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• Shaopeng Wang,

  Affiliation State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, China

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• Huanxiang Liu ,

  * E-mail: hxliu@lzu.edu.cn (HL); xjyao@lzu.edu.cn (XY)

  Affiliation School of Pharmacy, Lanzhou University, Lanzhou, China

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• Xiaojun Yao

  * E-mail: hxliu@lzu.edu.cn (HL); xjyao@lzu.edu.cn (XY)

  Affiliations State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, China, State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China

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