Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine

• Yifan Zhang ,

  Contributed equally to this work with: Yifan Zhang, Angéla Kecskés

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Angéla Kecskés ,

  Contributed equally to this work with: Yifan Zhang, Angéla Kecskés

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Daniëlle Copmans ,

  ¶‡ These authors also contributed equally to this work.

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Mélanie Langlois ,

  ¶‡ These authors also contributed equally to this work.

  Affiliation Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

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• Alexander D. Crawford,

  Affiliations Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

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• Berten Ceulemans,

  Affiliation Department of Neurology-Child Neurology, University Hospital Antwerp & University of Antwerp, Antwerp, Belgium

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• Lieven Lagae,

  Affiliation Department of Paediatric Neurology, University Hospitals Leuven, Leuven, Belgium

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• Peter A. M. de Witte ,

  * E-mail: peter.dewitte@pharm.kuleuven.be

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Camila V. Esguerra

  Current address: Chemical Neuroscience Group, Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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