Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms

Matthew Prideaux; Sarah L. Dallas; Ning Zhao; Erica D. Johnsrud; Patricia A. Veno; Dayong Guo; Yuji Mishina; Stephen E. Harris; Lynda F. Bonewald

doi:10.1371/journal.pone.0125731

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Peer-reviewed

Research Article

Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms

Matthew Prideaux,

Current address: Centre for Orthopaedic and Trauma Research, The University of Adelaide, Adelaide, Australia

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Sarah L. Dallas,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Ning Zhao,

Current address: Department of Orthodontics, Shanghai Key Laboratory of Stomatology, Shanghai No. 9 Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Erica D. Johnsrud,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Patricia A. Veno,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Dayong Guo,

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯
Yuji Mishina,

Affiliation Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Stephen E. Harris,

Affiliation Peridontics and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Lynda F. Bonewald

* E-mail: bonewaldl@umkc.edu

Affiliation Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of America
⨯

Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms

Matthew Prideaux,
Sarah L. Dallas,
Ning Zhao,
Erica D. Johnsrud,
Patricia A. Veno,
Dayong Guo,
Yuji Mishina,
Stephen E. Harris,
Lynda F. Bonewald

Published: May 5, 2015
https://doi.org/10.1371/journal.pone.0125731

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Osteocytes
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Cell motility
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Osteoblasts
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Calcium channels
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Gene expression
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Parathyroid hormone
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Osteoblast differentiation
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Polymerase chain reaction
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