Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy

Guanzhong Ni; Jiaming Qin; Hongliang Li; Ziyi Chen; Yafang Zhou; Ziyan Fang; Yishu Chen; Jueqian Zhou; Min Huang; Liemin Zhou

doi:10.1371/journal.pone.0125656

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Open Access

Peer-reviewed

Research Article

Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy

Guanzhong Ni ,

Contributed equally to this work with: Guanzhong Ni, Jiaming Qin

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Jiaming Qin ,

Contributed equally to this work with: Guanzhong Ni, Jiaming Qin

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Hongliang Li,

Affiliation Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Ziyi Chen,

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Yafang Zhou,

Affiliation Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Ziyan Fang,

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Yishu Chen,

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Jueqian Zhou,

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Min Huang,

Affiliation Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯
Liemin Zhou

* E-mail: lmzhou56@163.com

Affiliation Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China
⨯

Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy

Guanzhong Ni,
Jiaming Qin,
Hongliang Li,
Ziyi Chen,
Yafang Zhou,
Ziyan Fang,
Yishu Chen,
Jueqian Zhou,
Min Huang,
Liemin Zhou

Published: April 27, 2015
https://doi.org/10.1371/journal.pone.0125656

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