Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses

Danielle N. Renner; Fang Jin; Adam J. Litterman; Alexis J. Balgeman; Lisa M. Hanson; Jeffrey D. Gamez; Michael Chae; Brett L. Carlson; Jann N. Sarkaria; Ian F. Parney; John R. Ohlfest; Istvan Pirko; Kevin D. Pavelko; Aaron J. Johnson

doi:10.1371/journal.pone.0125565

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Open Access

Peer-reviewed

Research Article

Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses

Danielle N. Renner,

Affiliations Neurobiology of Disease Graduate Program, Mayo Clinic, Rochester, MN, United States of America, Department of Immunology, Mayo Clinic, Rochester, MN, United States of America
⨯
Fang Jin,

Affiliation Department of Immunology, Mayo Clinic, Rochester, MN, United States of America
⨯
Adam J. Litterman,

Affiliation Department of Neurosurgery, University of Minnesota, Minneapolis MN, United States of America
⨯
Alexis J. Balgeman,

Affiliation Summer Undergraduate Research Fellowship, Mayo Clinic, Rochester, MN, United States of America
⨯
Lisa M. Hanson,

Affiliation Department of Immunology, Mayo Clinic, Rochester, MN, United States of America
⨯
Jeffrey D. Gamez,

Affiliation Department of Neurology, Mayo Clinic, Rochester, MN, United States of America
⨯
Michael Chae,

Affiliation Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States of America
⨯
Brett L. Carlson,

Affiliation Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States of America
⨯
Jann N. Sarkaria,

Affiliation Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States of America
⨯
Ian F. Parney,

Affiliations Department of Immunology, Mayo Clinic, Rochester, MN, United States of America, Department of Neurosurgery, Mayo Clinic, Rochester, MN, United States of America
⨯
John R. Ohlfest,

Affiliation Department of Neurosurgery, University of Minnesota, Minneapolis MN, United States of America
⨯
Istvan Pirko,

Affiliation Department of Neurology, Mayo Clinic, Rochester, MN, United States of America
⨯
Kevin D. Pavelko ,

* E-mail: Johnson.Aaron2@mayo.edu (AJJ); Pavelko.Kevin@mayo.edu (KDP)

Affiliation Department of Immunology, Mayo Clinic, Rochester, MN, United States of America
⨯
Aaron J. Johnson

* E-mail: Johnson.Aaron2@mayo.edu (AJJ); Pavelko.Kevin@mayo.edu (KDP)

Affiliations Department of Immunology, Mayo Clinic, Rochester, MN, United States of America, Department of Neurology, Mayo Clinic, Rochester, MN, United States of America
⨯

Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses

Danielle N. Renner,
Fang Jin,
Adam J. Litterman,
Alexis J. Balgeman,
Lisa M. Hanson,
Jeffrey D. Gamez,
Michael Chae,
Brett L. Carlson,
Jann N. Sarkaria,
Ian F. Parney

Published: May 1, 2015
https://doi.org/10.1371/journal.pone.0125565

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