Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts

Rui Li; Jie Xiao; Xiaoteng Qing; Junhui Xing; Yanfei Xia; Jia Qi; Xiaojun Liu; Sen Zhang; Xi Sheng; Xinyu Zhang; Xiaoping Ji

doi:10.1371/journal.pone.0125513

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Peer-reviewed

Research Article

Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts

Rui Li,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Jie Xiao,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Xiaoteng Qing,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Junhui Xing,

Affiliations The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China, Department of Emergency, Qilu Hospital, Shandong University, Jinan, Shandong, China
⨯
Yanfei Xia,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Jia Qi,

Affiliation Department of Cardiology, Central Hospital of Zibo, Shandong, China
⨯
Xiaojun Liu,

Affiliation Department of Cardiology, Central Hospital of Zibo, Shandong, China
⨯
Sen Zhang,

Affiliation Department of Cardiology, Qilu Hospital of Shandong University, Qingdao, Shandong, China
⨯
Xi Sheng,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Xinyu Zhang,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯
Xiaoping Ji

* E-mail: jxp1964@hotmail.com

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, Jinan, Shandong, China
⨯

Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts

Rui Li,
Jie Xiao,
Xiaoteng Qing,
Junhui Xing,
Yanfei Xia,
Jia Qi,
Xiaojun Liu,
Sen Zhang,
Xi Sheng,
Xinyu Zhang

Published: April 29, 2015
https://doi.org/10.1371/journal.pone.0125513

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