A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

Open Access

Peer-reviewed

Research Article

Kareem N. Mohni,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Petria S. Thompson,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Jessica W. Luzwick,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Gloria G. Glick,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Christopher S. Pendleton,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Brian D. Lehmann,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Jennifer A. Pietenpol,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
David Cortez

* E-mail: david.cortez@vanderbilt.edu

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Small interfering RNA
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Cancer treatment
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DNA damage
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Non-small cell lung cancer
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DNA repair
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Transfection
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Breast cancer
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DNA replication
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