Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

• Sophie Candon ,

  Contributed equally to this work with: Sophie Candon, Alicia Perez-Arroyo

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Alicia Perez-Arroyo ,

  Contributed equally to this work with: Sophie Candon, Alicia Perez-Arroyo

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Cindy Marquet,

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Fabrice Valette,

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Anne-Perrine Foray,

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Benjamin Pelletier,

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Cristian Milani,

  Affiliation Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy

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• Marco Ventura,

  Affiliation Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy

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• Jean-François Bach,

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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• Lucienne Chatenoud

  * E-mail: lucienne.chatenoud@inserm.fr

  Affiliations Université Paris Descartes, Sorbonne Paris Cité, F-75475, Paris, France, INSERM U1151, Hôpital Necker-Enfants Malades, Paris, France, CNRS UMR 8253, Hôpital Necker-Enfants Malades, Paris, France

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