Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model

Jun Igarashi; Noboru Fukuda; Takashi Inoue; Shigeki Nakai; Kosuke Saito; Kyoko Fujiwara; Hiroyuki Matsuda; Takahiro Ueno; Yoshiaki Matsumoto; Takayoshi Watanabe; Hiroki Nagase; Toshikazu Bando; Hiroshi Sugiyama; Toshio Itoh; Masayoshi Soma

doi:10.1371/journal.pone.0125295

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Peer-reviewed

Research Article

Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model

Jun Igarashi,

Affiliation Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Noboru Fukuda ,

* E-mail: fukuda.noboru@nihon-u.ac.jp

Affiliations Division of Life Science, Advanced Research Institute for the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan, Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Takashi Inoue,

Affiliation Marmoset Research Department, Central Institute for Experimental Animals, Kanagawa, Japan
⨯
Shigeki Nakai,

Affiliation Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Kosuke Saito,

Affiliation Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Kyoko Fujiwara,

Affiliation Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Hiroyuki Matsuda,

Affiliation Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Takahiro Ueno,

Affiliation Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Yoshiaki Matsumoto,

Affiliation Department of Clinical Pharmacokinetics, College of Pharmacy, Nihon University, Chiba, Japan
⨯
Takayoshi Watanabe,

Affiliation Department of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯
Hiroki Nagase,

Affiliation Department of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯
Toshikazu Bando,

Affiliation Department of Chemistry, Kyoto University Graduate School, Kyoto, Japan
⨯
Hiroshi Sugiyama,

Affiliation Department of Chemistry, Kyoto University Graduate School, Kyoto, Japan
⨯
Toshio Itoh,

Affiliation Marmoset Research Department, Central Institute for Experimental Animals, Kanagawa, Japan
⨯
Masayoshi Soma

Affiliations Department of General Medicine, Nihon University School of Medicine, Tokyo, Japan, Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯

Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model

Jun Igarashi,
Noboru Fukuda,
Takashi Inoue,
Shigeki Nakai,
Kosuke Saito,
Kyoko Fujiwara,
Hiroyuki Matsuda,
Takahiro Ueno,
Yoshiaki Matsumoto,
Takayoshi Watanabe

Published: May 4, 2015
https://doi.org/10.1371/journal.pone.0125295

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