Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis: Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral Ischemia

Aixa F. Rivera-Pagán; David E. Rivera-Aponte; Katya V. Melnik-Martínez; Astrid Zayas-Santiago; Lilia Y. Kucheryavykh; Antonio H. Martins; Luis A. Cubano; Serguei N. Skatchkov; Misty J. Eaton

doi:10.1371/journal.pone.0125195

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Peer-reviewed

Research Article

Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis: Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral Ischemia

Aixa F. Rivera-Pagán ,

* E-mail: aixafernanda@gmail.com (AFRP); serguei.skatchkov@uccaribe.edu (SNS)

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
David E. Rivera-Aponte,

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Katya V. Melnik-Martínez,

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Astrid Zayas-Santiago,

Affiliation Department of Physiology, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Lilia Y. Kucheryavykh,

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Antonio H. Martins,

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Luis A. Cubano,

Affiliation Departments of Anatomy and Cell Biology, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Serguei N. Skatchkov ,

* E-mail: aixafernanda@gmail.com (AFRP); serguei.skatchkov@uccaribe.edu (SNS)

Affiliations Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America, Department of Physiology, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯
Misty J. Eaton

Affiliation Department of Biochemistry, Universidad Central del Caribe, Bayamón, Puerto Rico, United States of America
⨯

Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis: Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral Ischemia

Aixa F. Rivera-Pagán,
David E. Rivera-Aponte,
Katya V. Melnik-Martínez,
Astrid Zayas-Santiago,
Lilia Y. Kucheryavykh,
Antonio H. Martins,
Luis A. Cubano,
Serguei N. Skatchkov,
Misty J. Eaton

Published: April 17, 2015
https://doi.org/10.1371/journal.pone.0125195

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Astrocytes
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Ischemia
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Messenger RNA
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Protein synthesis
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Hypoxia
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Membrane proteins
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Potassium channels
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Proteolysis
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