Intermittent Induction of HIF-1α Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression

Hyunsung Choi; David L. Gillespie; Shauna Berg; Christopher Rice; Sandrine Couldwell; Jie Gu; Howard Colman; Randy L. Jensen; L. Eric Huang

doi:10.1371/journal.pone.0125125

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Peer-reviewed

Research Article

Intermittent Induction of HIF-1α Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression

Hyunsung Choi,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
David L. Gillespie,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Shauna Berg,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Christopher Rice,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Sandrine Couldwell,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Jie Gu,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Howard Colman,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
Randy L. Jensen,

Affiliation Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America
⨯
L. Eric Huang

* E-mail: eric.huang@hsc.utah.edu

Affiliations Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
⨯

Intermittent Induction of HIF-1α Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression

Hyunsung Choi,
David L. Gillespie,
Shauna Berg,
Christopher Rice,
Sandrine Couldwell,
Jie Gu,
Howard Colman,
Randy L. Jensen,
L. Eric Huang

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0125125

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Malignant tumors
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Cancers and neoplasms
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Hypoxia
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