Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3

Open Access

Peer-reviewed

Research Article

Jennifer M. Atkinson,

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Kenneth B. Rank,

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Yi Zeng,

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Andrew Capen,

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Vipin Yadav,

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Jason R. Manro,

Affiliation Statistics Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Thomas A. Engler,

Affiliation Discovery Chemistry Research and Technologies, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Marcio Chedid

* E-mail: chedid.marcio@lilly.com

Affiliation Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, United States of America
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Melanoma
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Melanoma cells
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Apoptosis
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Cancer treatment
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Wnt signaling cascade
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Malignant tumors
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Gene expression
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Cell signaling
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