Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis

Rou-Mu Hu; Bi-Hua Tan; David J. Tester; Chunhua Song; Yang He; Sinisa Dovat; Blaise Z. Peterson; Michael J. Ackerman; Jonathan C. Makielski

doi:10.1371/journal.pone.0124921

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Peer-reviewed

Research Article

Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis

Rou-Mu Hu ,

¶‡ RMH and BHT are co-first authors on this work.

Affiliations Department of Cardiology, China Meitan General Hospital, Beijing, China, Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin, Madison, WI, United States of America
⨯
Bi-Hua Tan ,

* E-mail: btan@hmc.psu.edu

¶‡ RMH and BHT are co-first authors on this work.

Affiliations Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin, Madison, WI, United States of America, Departments of Pediatrics, and Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, United States of America
⨯
David J. Tester,

Affiliation Departments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States of America
⨯
Chunhua Song,

Affiliation Departments of Pediatrics, and Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, United States of America
⨯
Yang He,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin, Madison, WI, United States of America
⨯
Sinisa Dovat,

Affiliation Departments of Pediatrics, and Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, United States of America
⨯
Blaise Z. Peterson,

Affiliation Departments of Pediatrics, and Cellular & Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, United States of America
⨯
Michael J. Ackerman,

Affiliation Departments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States of America
⨯
Jonathan C. Makielski

Affiliation Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin, Madison, WI, United States of America
⨯

Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis

Rou-Mu Hu,
Bi-Hua Tan,
David J. Tester,
Chunhua Song,
Yang He,
Sinisa Dovat,
Blaise Z. Peterson,
Michael J. Ackerman,
Jonathan C. Makielski

Published: April 29, 2015
https://doi.org/10.1371/journal.pone.0124921

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