Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer

Yukiharu Hiyoshi; Aaron J. Schetter; Hirokazu Okayama; Kentaro Inamura; Katsuhiro Anami; Giang H. Nguyen; Izumi Horikawa; Jason E. Hawkes; Elise D. Bowman; Suet Yi Leung; Curtis C. Harris

doi:10.1371/journal.pone.0124899

Loading metrics

Open Access

Peer-reviewed

Research Article

Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer

Yukiharu Hiyoshi ,

Contributed equally to this work with: Yukiharu Hiyoshi, Aaron J. Schetter

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Aaron J. Schetter ,

Contributed equally to this work with: Yukiharu Hiyoshi, Aaron J. Schetter

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Hirokazu Okayama,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Kentaro Inamura,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Katsuhiro Anami,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Giang H. Nguyen,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Izumi Horikawa,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Jason E. Hawkes,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Elise D. Bowman,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Suet Yi Leung,

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯
Curtis C. Harris

* E-mail: curtis_harris@nih.gov

Affiliation Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
⨯

Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer

Yukiharu Hiyoshi,
Aaron J. Schetter,
Hirokazu Okayama,
Kentaro Inamura,
Katsuhiro Anami,
Giang H. Nguyen,
Izumi Horikawa,
Jason E. Hawkes,
Elise D. Bowman,
Suet Yi Leung

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0124899

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Colorectal cancer
Is the Subject Area "Colorectal cancer" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
Colon
Is the Subject Area "Colon" applicable to this article?

Thanks for your feedback.
Prognosis
Is the Subject Area "Prognosis" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Epithelium
Is the Subject Area "Epithelium" applicable to this article?

Thanks for your feedback.