A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition

Adam R. Brown; Keivan A. Ettefagh; Daniel Todd; Patrick S. Cole; Joseph M. Egan; Daniel H. Foil; Tyler N. Graf; Bryan D. Schindler; Glenn W. Kaatz; Nadja B. Cech

doi:10.1371/journal.pone.0124814

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Peer-reviewed

Research Article

A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition

Adam R. Brown,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Keivan A. Ettefagh,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Daniel Todd,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Patrick S. Cole,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Joseph M. Egan,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Daniel H. Foil,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Tyler N. Graf,

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯
Bryan D. Schindler,

Affiliation Division of Infectious Disease, John Dingell Department of Veteran Affairs Medical Center and Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Glenn W. Kaatz,

Affiliation Division of Infectious Disease, John Dingell Department of Veteran Affairs Medical Center and Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Nadja B. Cech

* E-mail: nadja_cech@uncg.edu

Affiliation Department of Chemistry/Biochemistry, The University of North Carolina Greensboro, Greensboro, North Carolina, United States of America
⨯

A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition

Adam R. Brown,
Keivan A. Ettefagh,
Daniel Todd,
Patrick S. Cole,
Joseph M. Egan,
Daniel H. Foil,
Tyler N. Graf,
Bryan D. Schindler,
Glenn W. Kaatz,
Nadja B. Cech

Published: May 11, 2015
https://doi.org/10.1371/journal.pone.0124814

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