Single Chain Variable Fragment Against Aβ Expressed in Baculovirus Inhibits Abeta Fibril Elongation and Promotes its Disaggregation

Ying Zhang; Hai-Qiang Yang; Fang Fang; Lin-Lin Song; Yue-Ying Jiao; He Wang; Xiang-Lei Peng; Yan-Peng Zheng; Jun Wang; Jin-Sheng He; Tao Hung

doi:10.1371/journal.pone.0124736

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Open Access

Peer-reviewed

Research Article

Single Chain Variable Fragment Against Aβ Expressed in Baculovirus Inhibits Abeta Fibril Elongation and Promotes its Disaggregation

Ying Zhang ,

Contributed equally to this work with: Ying Zhang, Hai-Qiang Yang

* E-mail: yingzhang@bjtu.edu.cn

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Hai-Qiang Yang ,

Contributed equally to this work with: Ying Zhang, Hai-Qiang Yang

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Fang Fang,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Lin-Lin Song,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Yue-Ying Jiao,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
He Wang,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Xiang-Lei Peng,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Yan-Peng Zheng,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Jun Wang,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Jin-Sheng He,

Affiliation College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China
⨯
Tao Hung

Affiliations College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, China, Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
⨯

Single Chain Variable Fragment Against Aβ Expressed in Baculovirus Inhibits Abeta Fibril Elongation and Promotes its Disaggregation

Ying Zhang,
Hai-Qiang Yang,
Fang Fang,
Lin-Lin Song,
Yue-Ying Jiao,
He Wang,
Xiang-Lei Peng,
Yan-Peng Zheng,
Jun Wang,
Jin-Sheng He

Published: April 28, 2015
https://doi.org/10.1371/journal.pone.0124736

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