Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

Joaquim Bellmunt; Lillian Werner; Jeffrey J. Leow; Stephanie A. Mullane; André P. Fay; Markus Riester; Paul Van Hummelen; Mary-Ellen Taplin; Toni K. Choueiri; Eliezer Van Allen; Jonathan Rosenberg

doi:10.1371/journal.pone.0124711

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Research Article

Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

Joaquim Bellmunt ,

* E-mail: joaquim_bellmunt@dfci.harvard.edu

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Lillian Werner,

Affiliation Biostatistics and Computational Biology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, United States of America
⨯
Jeffrey J. Leow,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Stephanie A. Mullane,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
André P. Fay,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Markus Riester,

Affiliation Biostatistics and Computational Biology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, United States of America
⨯
Paul Van Hummelen,

Affiliation Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, United States of America
⨯
Mary-Ellen Taplin,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Toni K. Choueiri,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Eliezer Van Allen,

Affiliation Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Jonathan Rosenberg

Affiliation Memorial Sloan Kettering Cancer Center, New York, NY, United States of America
⨯

Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

Joaquim Bellmunt,
Lillian Werner,
Jeffrey J. Leow,
Stephanie A. Mullane,
André P. Fay,
Markus Riester,
Paul Van Hummelen,
Mary-Ellen Taplin,
Toni K. Choueiri,
Eliezer Van Allen

Published: June 3, 2015
https://doi.org/10.1371/journal.pone.0124711

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