A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells

• Venkateswara R. Simhadri ,

  * E-mail: venkateswara.simhadri@fda.hhs.gov (VS); francisco.borregorabasco@osakidetza.net (FB)

  Affiliation Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Milena Dimitrova,

  Affiliation Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• John L. Mariano,

  Affiliation Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Olatz Zenarruzabeitia,

  Affiliations Immunopathology Group, BioCruces Health Research Institute, Barakaldo, Basque Country, Spain, Cell Therapy and Stem Cell Group, Basque Center for Transfusion and Human Tissues, Galdakao, Basque Country, Spain

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• Weimin Zhong,

  Affiliation Influenza Division, National Center for Immunization and Respiratory Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, United States of America

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• Tatsuhiko Ozawa,

  Affiliation Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama Prefecture, Japan

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• Atsushi Muraguchi,

  Affiliation Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama Prefecture, Japan

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• Hiroyuki Kishi,

  Affiliation Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama Prefecture, Japan

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• Maryna C. Eichelberger,

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Francisco Borrego

  * E-mail: venkateswara.simhadri@fda.hhs.gov (VS); francisco.borregorabasco@osakidetza.net (FB)

  Affiliations Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America, Immunopathology Group, BioCruces Health Research Institute, Barakaldo, Basque Country, Spain, Ikerbasque, Basque Foundation for Science, Bilbao, Basque Country, Spain

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