A Novel Quantitative Hemolytic Assay Coupled with Restriction Fragment Length Polymorphisms Analysis Enabled Early Diagnosis of Atypical Hemolytic Uremic Syndrome and Identified Unique Predisposing Mutations in Japan

• Yoko Yoshida,

  Affiliation Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

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• Toshiyuki Miyata,

  Affiliation Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan

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• Masanori Matsumoto,

  Affiliation Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

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• Hiroko Shirotani-Ikejima,

  Affiliation Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan

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• Yumiko Uchida,

  Affiliation Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan

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• Yoshifumi Ohyama,

  Affiliation Molecular and Cellular Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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• Tetsuro Kokubo,

  Affiliation Molecular and Cellular Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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• Yoshihiro Fujimura

  * E-mail: yoshifuji325@naramed-u.ac.jp

  Affiliation Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan

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