Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes

Patrizia Fabbi; Paolo Spallarossa; Silvano Garibaldi; Chiara Barisione; Marzia Mura; Paola Altieri; Barbara Rebesco; Maria Gaia Monti; Marco Canepa; Giorgio Ghigliotti; Claudio Brunelli; Pietro Ameri

doi:10.1371/journal.pone.0124643

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Open Access

Peer-reviewed

Research Article

Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes

Patrizia Fabbi,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Paolo Spallarossa,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Silvano Garibaldi,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Chiara Barisione,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Marzia Mura,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Paola Altieri,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Barbara Rebesco,

Affiliation Antiblastic Drug Unit, IRCCS AOU San Martino-IST, Genova, Italy
⨯
Maria Gaia Monti,

Affiliation Department of Medical Translational Sciences, University of Napoli Federico II, Napoli, Italy
⨯
Marco Canepa,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Giorgio Ghigliotti,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Claudio Brunelli,

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯
Pietro Ameri

* E-mail: pietroameri@unige.it

Affiliation Research Center of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Genova, Italy
⨯

Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes

Patrizia Fabbi,
Paolo Spallarossa,
Silvano Garibaldi,
Chiara Barisione,
Marzia Mura,
Paola Altieri,
Barbara Rebesco,
Maria Gaia Monti,
Marco Canepa,
Giorgio Ghigliotti

Published: May 8, 2015
https://doi.org/10.1371/journal.pone.0124643

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Iodides
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