Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

Sarah Triboulet; Catherine Aude-Garcia; Lucie Armand; Véronique Collin-Faure; Mireille Chevallet; Hélène Diemer; Adèle Gerdil; Fabienne Proamer; Jean-Marc Strub; Aurélie Habert; Nathalie Herlin; Alain Van Dorsselaer; Marie Carrière; Thierry Rabilloud

doi:10.1371/journal.pone.0124496

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Peer-reviewed

Research Article

Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

Sarah Triboulet,

Affiliation Laboratory of Chemistry and Biology of Metals, Univ. Grenoble Alpes, Grenoble, France
⨯
Catherine Aude-Garcia,

Affiliations Laboratory of Chemistry and Biology of Metals, CEA/ iRTSV, Grenoble, France, Laboratory of Chemistry and Biology of Metals, CNRS UMR5249, Grenoble, France
⨯
Lucie Armand,

Affiliation Service de Chimie Inorganique et Biologique, Univ. Grenoble Alpes & CEA, Grenoble, France
⨯
Véronique Collin-Faure,

Affiliation Laboratory of Chemistry and Biology of Metals, CEA/ iRTSV, Grenoble, France
⨯
Mireille Chevallet,

Affiliation Laboratory of Chemistry and Biology of Metals, CEA/ iRTSV, Grenoble, France
⨯
Hélène Diemer,

Affiliation Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg & CNRS UMR 7178, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France
⨯
Adèle Gerdil,

Affiliation Laboratoire Francis Perrin (Unité de recherche Associée 2453), Commissariat à l’Energie Atomique, CEA-Saclay 91191 Gif/Yvette, France
⨯
Fabienne Proamer,

Affiliation Etablissement Français du Sang-Alsace, Unité MIxte de recherche S949 Institut National de la Santé Et de la Recherche Médicale (INSERM)-Université de Strasbourg, Strasbourg, France
⨯
Jean-Marc Strub,

Affiliation Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg & CNRS UMR 7178, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France
⨯
Aurélie Habert,

Affiliation Laboratoire Francis Perrin (Unité de recherche Associée 2453), Commissariat à l’Energie Atomique, CEA-Saclay 91191 Gif/Yvette, France
⨯
Nathalie Herlin,

Affiliation Laboratoire Francis Perrin (Unité de recherche Associée 2453), Commissariat à l’Energie Atomique, CEA-Saclay 91191 Gif/Yvette, France
⨯
Alain Van Dorsselaer,

Affiliation Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Université de Strasbourg & CNRS UMR 7178, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France
⨯
Marie Carrière,

Affiliation Service de Chimie Inorganique et Biologique, Univ. Grenoble Alpes & CEA, Grenoble, France
⨯
Thierry Rabilloud

* E-mail: thierry.rabilloud@cea.fr

Affiliation Laboratory of Chemistry and Biology of Metals, CNRS UMR5249, Grenoble, France
⨯

Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

Sarah Triboulet,
Catherine Aude-Garcia,
Lucie Armand,
Véronique Collin-Faure,
Mireille Chevallet,
Hélène Diemer,
Adèle Gerdil,
Fabienne Proamer,
Jean-Marc Strub,
Aurélie Habert

Published: April 22, 2015
https://doi.org/10.1371/journal.pone.0124496

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