The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines

Sabrina M. de Munnik; Albert J. Kooistra; Jody van Offenbeek; Saskia Nijmeijer; Chris de Graaf; Martine J. Smit; Rob Leurs; Henry F. Vischer

doi:10.1371/journal.pone.0124486

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Peer-reviewed

Research Article

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines

Sabrina M. de Munnik,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Albert J. Kooistra,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Jody van Offenbeek,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Saskia Nijmeijer,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Chris de Graaf,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Martine J. Smit,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Rob Leurs,

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯
Henry F. Vischer

* E-mail: h.f.vischer@vu.nl

Affiliation Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands
⨯

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines

Sabrina M. de Munnik,
Albert J. Kooistra,
Jody van Offenbeek,
Saskia Nijmeijer,
Chris de Graaf,
Martine J. Smit,
Rob Leurs,
Henry F. Vischer

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0124486

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